3-CHLORO-4-ISOPROPOXY-BENZOIC ACID

Base Information

• Chemical Name: 3-CHLORO-4-ISOPROPOXY-BENZOIC ACID
• CAS No.: 213598-07-3
• Molecular Formula: C10H11ClO3
• Molecular Weight: 214.649
• Hs Code.: 2918990090
• Mol file: 213598-07-3.mol

Synonyms:3-Chloro-4-[(1-methylethyl)oxy]benzoicacid;3-Chloro-4-isopropoxybenzoic acid;

Chemical Property of 3-CHLORO-4-ISOPROPOXY-BENZOIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.543
• Boiling Point: 322.9 °C at 760 mmHg
• Flash Point: 149.073 °C
• PSA: 46.53000
• Density: 1.253 g/cm³
• LogP: 2.82540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-4-isopropoxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-4-ISOPROPOXY-BENZOIC ACID

There total 13 articles about 3-CHLORO-4-ISOPROPOXY-BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-hydroxy-3-chlorobenzoate (3964-57-6) + isopropyl bromide (75-26-3) → 3-chloro-4-isopropoxy-benzoic acid (213598-07-3)

Guidance literature:

methyl 4-hydroxy-3-chlorobenzoate; isopropyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 16h;

With sodium hydroxide; In methanol; water; at 60 ℃; for 2h;

With hydrogenchloride; In water;

DOI:10.1021/jm5010336

Reference yield: 98.0%

→ 3-chloro-4-isopropoxy-benzoic acid (213598-07-3)

Guidance literature:

Reference yield: 88.0%

4-isopropoxybenzoic acid (13205-46-4) → 3-chloro-4-isopropoxy-benzoic acid (213598-07-3)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 3-chloro-4-isopropoxybenzoate

4-isopropoxybenzoic acid

3-chloro-4-isopropoxy-benzoic acid ethyl ester

methyl 4-hydroxy-3-chlorobenzoate

Downstream raw materials:

pentafluorophenyl 3-chloro-4-[(1-methylethyl)oxy]benzoate

(3-chloro-4-isopropoxyphenyl)methanol

[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]methanol

3-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indol-1-yl]propanoic acid