(4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:(4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester
CAS No.:1055036-36-6
Molecular Formula:C₂₂H₂₅NO₅
Molecular Weight:383.444
Hs Code.:

Synonyms:(4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

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Chemical Property of (4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

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Technology Process of (4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

There total 15 articles about (4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-84-8
4-benzyloxybutanal

: 1055036-36-6
(4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: L-threonine aldolase / 5 h

2: triethylamine / CH₂Cl₂ / 1 h / 0 °C

3: methanol; diethyl ether

4: thionyl chloride / 60 h / 20 °C

5: DBU / dimethylformamide / 1 h / 20 °C

With thionyl chloride; L-threonine aldolase; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Addition / 2: Acylation / 3: Methylation / 4: Cyclization / 5: hydroxymethylation;
DOI:10.3987/com-99-s117

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 1055036-36-6
(4S,5S)-5-(3-Benzyloxy-propyl)-4-hydroxymethyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 3 h / -78 °C

2: L-threonine aldolase / 5 h

3: triethylamine / CH₂Cl₂ / 1 h / 0 °C

4: methanol; diethyl ether

5: thionyl chloride / 60 h / 20 °C

6: DBU / dimethylformamide / 1 h / 20 °C

With thionyl chloride; oxalyl dichloride; L-threonine aldolase; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Oxidation / 2: Addition / 3: Acylation / 4: Methylation / 5: Cyclization / 6: hydroxymethylation;
DOI:10.3987/com-99-s117