thymidilyl(3'-5')thymidine

Base Information

• Chemical Name: thymidilyl(3'-5')thymidine
• CAS No.: 87367-14-4
• Molecular Formula: C₂₀H₂₆N₄O₁₂P
• Molecular Weight: 545.42
• Mol file: 87367-14-4.mol

Synonyms:thymidilyl(3'-5')thymidine

Chemical Property of thymidilyl(3'-5')thymidine

Chemical Property:

Purity/Quality:

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Technology Process of thymidilyl(3'-5')thymidine

There total 1 articles about thymidilyl(3'-5')thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-thymidine-5'-thymidine-N-methoxyphosphoramidate (161762-47-6) → thymidilyl(3'-5')thymidine (87367-14-4) + C11H17N3O8P(1-) + C11H17N3O8P(1-) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4)

Guidance literature:

With ammonium hydroxide; In methanol; at 55 ℃; stability under basic conditions (aq. NH₃ or aq. NaOH solutions);

DOI:10.1080/15257779408013213

Reference yield: 4.0%

[Zn(benzyl-1,4,7,10-tetraazacyclododecane)(H2O)](2+) (215235-90-8) + thymidilyl(3'-5')thymidine (87367-14-4) → [Zn2(benzyl-1,4,7,10-tetraazacyclododecane)2(C20H24N4PO12)](1+)

Guidance literature:

With sodium nitrate; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; In water; 25°C, pH=7.6, ratio Zn-complex/thymidine phosphate 2:1;

DOI:10.1021/ja981788c

Reference yield:

thymidilyl(3'-5')thymidine (87367-14-4) → thymidine 3'-monophosphate + thymidine-5'-monophosphate dianion (14057-65-9) + thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4)

Guidance literature:

With hydroxide; In water; at 80 ℃; pH=14; Kinetics;

DOI:10.1021/jo000323d

upstream raw materials:

3'-thymidine-5'-thymidine-N-methoxyphosphoramidate

Downstream raw materials:

thymidine-5'-monophosphate dianion

thymidine

thyminyl-(6-4')-(5'-methyl-1',2'-dihydropyrimidin-2'-one)

(5-hydroxy-5,6-dihydrothyminyl)-(6-4')(5'-methyl-1',2'-dihydropyrimidin-2'-one)