(S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide

Base Information

Chemical Name:(S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide
CAS No.:1025472-17-6
Molecular Formula:C₂₁H₂₂N₂O₂S
Molecular Weight:366.484
Hs Code.:

Synonyms:(S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide

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Technology Process of (S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide

There total 1 articles about (S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96-50-4
2-thiazolylamine

: 1025475-79-9
(S)-3-(4-methoxyphenyl)-2,2-dimethyl-3-phenylpropanoic acid

: 1025472-17-6
(S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 75 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm100957a

Reference yield: 62.3%

: 1025472-17-6
(S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide

: 75-36-5
acetyl chloride

: 1309960-42-6
3-(3-acetyl-4-methoxy-phenyl)-2,2-dimethyl-3-phenyl-N-(thiazol-2-yl)propanamide

Guidance literature:: acetyl chloride; With aluminum (III) chloride; In nitrobenzene; at 20 ℃; for 0.166667h; Inert atmosphere;

(S)-2,2-dimethyl-3-(4-(methyloxy)phenyl)-3-phenyl-N-1,3-thiazol-2-ylpropanamide; In nitrobenzene; 1,2-dichloro-ethane; at 20 ℃; for 1.5h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jm100957a