Technology Process of (2R,3S)-N-benzoxycarbonyl-3-hydroxymethyl-3-methoxymethyloxypyrrolidine
There total 6 articles about (2R,3S)-N-benzoxycarbonyl-3-hydroxymethyl-3-methoxymethyloxypyrrolidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium borohydride;
In
diethyl ether;
at 0 ℃;
for 4h;
DOI:10.1139/v00-043
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / acetonitrile / 1 h / 0 °C
2: t-BuOK / toluene / 0.5 h / 0 °C
3: 45 percent / sucrose; baker's yeast / H2O / 48 h / 40 °C
4: 92 percent / diisopropylethylamine / CH2Cl2 / 24 h / 20 °C
5: 72 percent / LiBH4 / diethyl ether / 4 h / 0 °C
With
lithium borohydride; baker's yeast; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; Sucrose;
In
diethyl ether; dichloromethane; water; toluene; acetonitrile;
1: Condensation / 2: Dickemann cyclization / 3: Reduction / 4: Etherification / 5: Reduction;
DOI:10.1139/v00-043
- Guidance literature:
-
Multi-step reaction with 4 steps
1: t-BuOK / toluene / 0.5 h / 0 °C
2: 45 percent / sucrose; baker's yeast / H2O / 48 h / 40 °C
3: 92 percent / diisopropylethylamine / CH2Cl2 / 24 h / 20 °C
4: 72 percent / LiBH4 / diethyl ether / 4 h / 0 °C
With
lithium borohydride; baker's yeast; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; Sucrose;
In
diethyl ether; dichloromethane; water; toluene;
1: Dickemann cyclization / 2: Reduction / 3: Etherification / 4: Reduction;
DOI:10.1139/v00-043
