2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide

Base Information

• Chemical Name: 2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide
• CAS No.: 905600-51-3
• Molecular Formula: C₁₃H₉Cl₂FN₂O
• Molecular Weight: 299.132
• Mol file: 905600-51-3.mol

Synonyms:2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide

Chemical Property of 2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide

There total 4 articles about 2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-fluorobenzoic acid (403-16-7) → 2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide (905600-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: s-BuLi; TMEDA / tetrahydrofuran / -78 °C

1.2: Cl₃CCCl₃

2.1: SOCl₂; DMF / toluene / Heating

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;

DOI:10.1021/jm051202e

Reference yield:

2,3-Dichloro-4-fluoro-benzoic acid (154257-76-8) → 2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide (905600-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂; DMF / toluene / Heating

With thionyl chloride; N,N-dimethyl-formamide; In toluene;

DOI:10.1021/jm051202e

Reference yield:

2,3-dichloro-4-fluorobenzoyl chloride + 3-Aminomethylpyridine (3731-52-0) → 2,3-dichloro-4-fluoro-N-pyridin-3-ylmethylbenzamide (905600-51-3)

Guidance literature:

DOI:10.1021/jm051202e

upstream raw materials:

3-Aminomethylpyridine

3-chloro-4-fluorobenzoic acid

2,3-Dichloro-4-fluoro-benzoic acid