(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

Base Information

Chemical Name:(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde
CAS No.:73542-00-4
Molecular Formula:C₂₉H₄₄ClNO₆S₂
Molecular Weight:602.256
Hs Code.:

(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

Synonyms:(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

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Chemical Property of (2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

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Technology Process of (2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

There total 5 articles about (2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (2S,3S,4S)-5-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-4-(2-methoxy-ethoxymethoxy)-3-methyl-pentane-1,2-diol

: 73542-00-4
(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

Guidance literature:: With lead(IV) acetate; potassium acetate; In acetonitrile; at -25 ℃;
DOI:10.1021/ja00524a046

Reference yield:

: [2-Chloro-5-((2E,4E)-(R)-6-{2-[(2S,3R)-3-(S)-1,4-dioxa-spiro[4.4]non-2-yl-2-(2-methoxy-ethoxymethoxy)-butyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-amine

: 73542-00-4
(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / 0.3 M HClO₄ / acetonitrile; H₂O / 40 h / 0 °C

2: 95 percent / Pb(OAc)4, AcOK / acetonitrile / -25 °C

With lead(IV) acetate; perchloric acid; potassium acetate; In water; acetonitrile;
DOI:10.1021/ja00524a046

Reference yield:

: 73541-99-8
[2-Chloro-5-((2E,4E)-(R)-6-{2-[(2S,3R)-3-(S)-1,4-dioxa-spiro[4.4]non-2-yl-2-(2-methoxy-ethoxymethoxy)-butyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester

: 73542-00-4
(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium thiomethoxide, 2.) CH₃I, K₂CO₃ / 1.) DMF, 0 deg C, 40 h, 2.) acetone, 23 deg C

2: 87 percent / 0.3 M HClO₄ / acetonitrile; H₂O / 40 h / 0 °C

3: 95 percent / Pb(OAc)4, AcOK / acetonitrile / -25 °C

With lead(IV) acetate; perchloric acid; potassium acetate; lithium methanethiolate; potassium carbonate; methyl iodide; In water; acetonitrile;
DOI:10.1021/ja00524a046