(2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid

Base Information

• Chemical Name: (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid
• CAS No.: 73542-03-7
• Molecular Formula: C₃₄H₅₀ClNO₇S₂
• Molecular Weight: 684.359
• Mol file: 73542-03-7.mol

Synonyms:(2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid

Chemical Property of (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid

There total 8 articles about (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C5H10LiO5P + (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid methyl ester (73542-02-6) → (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid (73542-03-7)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 6h;

DOI:10.1021/ja00524a046

Reference yield:

(2S,3S,4S)-5-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-4-(2-methoxy-ethoxymethoxy)-3-methyl-pentane-1,2-diol → (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid (73542-03-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / Pb(OAc)4, AcOK / acetonitrile / -25 °C

2: 2.) pyridinium chloride / 1.) -110 deg C, 5 min, -78 deg C, 10 min, 2.) CH₂Cl₂, 20 deg C, 2 h

3: 96 percent / tetrahydrofuran / 6 h / 20 °C

4: 90 percent / 0.2 M tetra-n-butylammonium hydroxide / tetrahydrofuran; H₂O / 6 h / 20 °C

With lead(IV) acetate; tetra(n-butyl)ammonium hydroxide; potassium acetate; pyridine hydrochloride; In tetrahydrofuran; water; acetonitrile;

DOI:10.1021/ja00524a046

Reference yield:

(E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal (73542-01-5) → (2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid (73542-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / tetrahydrofuran / 6 h / 20 °C

2: 90 percent / 0.2 M tetra-n-butylammonium hydroxide / tetrahydrofuran; H₂O / 6 h / 20 °C

With tetra(n-butyl)ammonium hydroxide; In tetrahydrofuran; water;

DOI:10.1021/ja00524a046

upstream raw materials:

(2E,4E)-(6S,7S)-8-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-7-(2-methoxy-ethoxymethoxy)-4,6-dimethyl-octa-2,4-dienoic acid methyl ester

(2R,3S)-4-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-3-(2-methoxy-ethoxymethoxy)-2-methyl-butyraldehyde

(E)-(4S,5S)-6-{2-[(2E,4E)-(R)-6-(4-Chloro-3-methoxy-5-methylamino-phenyl)-1-methoxy-5-methyl-hexa-2,4-dienyl]-[1,3]dithian-2-yl}-5-(2-methoxy-ethoxymethoxy)-2,4-dimethyl-hex-2-enal

[2-Chloro-5-((2E,4E)-(R)-6-{2-[(2S,3R)-3-(S)-1,4-dioxa-spiro[4.4]non-2-yl-2-(2-methoxy-ethoxymethoxy)-butyl]-[1,3]dithian-2-yl}-6-methoxy-2-methyl-hexa-2,4-dienyl)-3-methoxy-phenyl]-methyl-carbamic acid methyl ester