methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Base Information

Chemical Name:methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate
CAS No.:347423-82-9
Molecular Formula:C₃₉H₄₀N₂O₁₀
Molecular Weight:696.754
Hs Code.:

methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Synonyms:methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Suppliers and Price of methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

There total 9 articles about methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-benzyloxy-2-(4-tert-butoxycarbonylamino-phenyl)-4-(3,4-dimethoxy-5-methoxymethoxy-phenyl)-1-oxo-1,2-dihydro-isoquinoline-3-carboxylic acid

: 74-88-4
methyl iodide

: 347423-82-9
methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1021/jm000558h

Reference yield:

: 81418-49-7
5-(benzyloxy)-2-bromobenzaldehyde dimethylacetal

: 347423-82-9
methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran / 0.5 h / -40 °C

2.1: 65 percent / 2 N aq. HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 4 h / Heating

6.1: i-Pr₂NEt / dimethylformamide / 20 °C

7.1: 2 N aq. NaOH; MeOH / tetrahydrofuran / 0.5 h / 20 °C

7.2: various solvent(s) / 2 h / 100 °C

8.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; N-ethyl-N,N-diisopropylamine; recorcinol; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h

Reference yield:

: N,N-dimethyl-4,5-dimethoxy-3-(methoxymethoxy)benzamide

: 347423-82-9
methyl 2-[(4-tert-butoxycarbonylamino)phenyl]-7-benzyloxy-4-[(4,5-dimethoxy-3-methoxymethyl)phenyl]-1,2-dihydro-1-oxo-3-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 83 percent / tetrahydrofuran / 0.5 h / -40 °C

2.1: 65 percent / 2 N aq. HCl / tetrahydrofuran / 20 °C

3.1: resorcinol; acetate buffer; NaClO₂ / dioxane; H₂O / 20 °C / pH 3.8

4.1: K₂CO₃ / dimethylformamide / 20 °C

5.1: 4 N HCl / ethyl acetate / 20 °C

5.2: AcOH / dioxane / 4 h / Heating

6.1: i-Pr₂NEt / dimethylformamide / 20 °C

7.1: 2 N aq. NaOH; MeOH / tetrahydrofuran / 0.5 h / 20 °C

7.2: various solvent(s) / 2 h / 100 °C

8.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; sodium chlorite; n-butyllithium; acetate buffer; potassium carbonate; N-ethyl-N,N-diisopropylamine; recorcinol; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm000558h