3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride

Base Information

Chemical Name:3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride
CAS No.:1439206-47-9
Molecular Formula:C₂₂H₂₆F₃NO₃*ClH
Molecular Weight:445.909
Hs Code.:

Synonyms:3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride

Chemical Property:

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Technology Process of 3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride

There total 6 articles about 3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.8%

: 1439437-79-2
C₂₂H₂₆F₃NO₃

: 1439206-47-9
3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether;
DOI:10.1016/j.ejmech.2013.02.013

Reference yield:

: 1443143-90-5
(E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

: 1439206-47-9
3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 1.17 h / 20 °C / 760.05 Torr / Inert atmosphere

2: sodium hydroxide / 7 h / 20 °C / Reflux

3: 6 h / Reflux

4: hydrogenchloride / diethyl ether

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; sodium hydroxide; In methanol; diethyl ether;
DOI:10.1016/j.ejmech.2013.02.013

Reference yield:

: 1443143-89-2
1-(2-hydroxy-phenyl)-3-(2-trifluoromethylphenyl)-propan-1-one

: 1439206-47-9
3-(2-trifluoromethylphenyl)-1-[2-(2-hydroxy-3-propylaminopropoxy)phenyl]-propan-1-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 7 h / 20 °C / Reflux

2: 6 h / Reflux

3: hydrogenchloride / diethyl ether

With hydrogenchloride; sodium hydroxide; In diethyl ether;
DOI:10.1016/j.ejmech.2013.02.013