(E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

Base Information

Chemical Name:(E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one
CAS No.:1443143-90-5
Molecular Formula:C₁₆H₁₁F₃O₂
Molecular Weight:292.257
Hs Code.:

Synonyms:(E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

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Technology Process of (E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

There total 1 articles about (E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 1443143-90-5
(E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

Guidance literature:: With sodium hydroxide; In ethanol; water; at 0 - 20 ℃;
DOI:10.1016/j.ejmech.2013.02.013

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 1443143-90-5
(E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

: (2-hydroxyphenyl)((1R,2R,3S)-3-phenyl-2-(2-(trifluoromethyl)phenyl)cyclobutyl)methanone

: (2-hydroxyphenyl)((1R,2R,3R)-3-phenyl-2-(2-(trifluoromethyl)phenyl)cyclobutyl)methanone

Guidance literature:: With Ru(4,4’-bipyridine)₃(PF₆)₂; 2,6-bis[4’-(S)-(tert-butyl)oxazolin-2’-yl]pyridine; scandium tris(trifluoromethanesulfonate); In Isopropyl acetate; acetonitrile; at 20 ℃; for 20h; Overall yield = 95 %; Overall yield = 151 mg; enantioselective reaction; Irradiation; Sealed tube;
DOI:10.1002/anie.201706975

Reference yield:

: 1443143-90-5
(E)-1-(2-hydroxy-phenyl)-3-(2-(trifluoromethyl)-phenyl)-prop-2-en-1-one

: 1443143-91-6
C₁₉H₁₇F₃O₃

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 1.17 h / 20 °C / 760.05 Torr / Inert atmosphere

2: sodium hydroxide / 7 h / 20 °C / Reflux

With 5%-palladium/activated carbon; hydrogen; sodium hydroxide; In methanol;
DOI:10.1016/j.ejmech.2013.02.013