(S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

Base Information

Chemical Name:(S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate
CAS No.:1198320-02-3
Molecular Formula:C₂₂H₂₄F₃NO₆S
Molecular Weight:487.497
Hs Code.:

Synonyms:(S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

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Chemical Property of (S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

Chemical Property:

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Technology Process of (S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

There total 2 articles about (S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198320-00-1
(S)-2-acetoxy-2-(3-(trifluoromethyl)phenyl)acetic acid

: 1198320-01-2
(2-methanesulfonyl-ethyl)-(4-methoxy-benzyl)-amine hydrochloride

: 1198320-02-3
(S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

Guidance literature:: (2-methanesulfonyl-ethyl)-(4-methoxy-benzyl)-amine hydrochloride; With caesium carbonate; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

(S)-2-acetoxy-2-(3-(trifluoromethyl)phenyl)acetic acid; In tetrahydrofuran; water; toluene; at 20 ℃; for 0.5h;

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; water; toluene; at -5 ℃; for 16h; optical yield given as %ee;
DOI:10.1016/j.tet.2009.09.054

Reference yield:

: 1198320-00-1
(S)-2-acetoxy-2-(3-(trifluoromethyl)phenyl)acetic acid

: 1198320-01-2
(2-methanesulfonyl-ethyl)-(4-methoxy-benzyl)-amine hydrochloride

: 1198320-02-3
(S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

: (R)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

Guidance literature:: (2-methanesulfonyl-ethyl)-(4-methoxy-benzyl)-amine hydrochloride; With caesium carbonate; In tetrahydrofuran; water; at 20 ℃; for 1.5h;

(S)-2-acetoxy-2-(3-(trifluoromethyl)phenyl)acetic acid; In tetrahydrofuran; water; toluene; at 20 ℃; for 0.5h;

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; water; toluene; at 25 ℃;
DOI:10.1016/j.tet.2009.09.054

Reference yield: 84.0%

: 1198320-02-3
(S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate

: 1198320-03-4
(S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)ethyl)-amino)-1-(3-(trifluoromethyl)phenyl)ethanol

Guidance literature:: (S)-2-((4-methoxybenzyl)(2-(methylsulfonyl)-ethyl)amino)-2-oxo-1-(3-(trifluoromethyl)phenyl)ethyl acetate; With borane-THF; In toluene; at 20 ℃; for 21h;

With sodium hydroxide; In water; toluene; at 10 - 50 ℃; for 2.66667h;
DOI:10.1016/j.tet.2009.09.054