Technology Process of [(1R,2R,3R,4R,6S,7R)-2,3-di(t-butyldimethylsilyloxy)-4-(t-butyldimethylsilyloxymethyl)bicyclo[4.1.0]hept-7-yl]methyl 2,4-dinitrophenyl ether
There total 9 articles about [(1R,2R,3R,4R,6S,7R)-2,3-di(t-butyldimethylsilyloxy)-4-(t-butyldimethylsilyloxymethyl)bicyclo[4.1.0]hept-7-yl]methyl 2,4-dinitrophenyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
1,2-dichloro-ethane;
at 40 ℃;
for 24h;
DOI:10.1081/CAR-200067125
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1.5 g / imidazole / dimethylformamide / 24 h / 60 °C
2.1: diphenyl ether / 2 h / 210 °C
2.2: 86 percent / sodium borohydride / tetrahydrofuran / 1 h / 20 °C
3.1: 91 percent / imidazole / dimethylformamide / 0.5 h / 20 °C
4.1: 71 percent / rhodium(II) acetate dimer / CH2Cl2 / 20 h / 20 °C
5.1: 87 percent / lithium aluminium hydride / tetrahydrofuran / 0.08 h / 0 °C
6.1: 91 percent / triethylamine / 1,2-dichloro-ethane / 24 h / 40 °C
With
1H-imidazole; dirhodium tetraacetate; lithium aluminium tetrahydride; triethylamine;
In
tetrahydrofuran; diphenylether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
2.1: Claisen rearrangement;
DOI:10.1081/CAR-200067125
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 92 percent / zinc; ammonium chloride; VO(salen) / methanol / 0.17 h
2.1: sodium methoxide / methanol / 0.5 h / 20 °C
3.1: 1.5 g / imidazole / dimethylformamide / 24 h / 60 °C
4.1: diphenyl ether / 2 h / 210 °C
4.2: 86 percent / sodium borohydride / tetrahydrofuran / 1 h / 20 °C
5.1: 91 percent / imidazole / dimethylformamide / 0.5 h / 20 °C
6.1: 71 percent / rhodium(II) acetate dimer / CH2Cl2 / 20 h / 20 °C
7.1: 87 percent / lithium aluminium hydride / tetrahydrofuran / 0.08 h / 0 °C
8.1: 91 percent / triethylamine / 1,2-dichloro-ethane / 24 h / 40 °C
With
1H-imidazole; dirhodium tetraacetate; lithium aluminium tetrahydride; (N,N'-ethylenebis(salicylideneaminato))oxovanadium(IV); ammonium chloride; sodium methylate; triethylamine; zinc;
In
tetrahydrofuran; methanol; diphenylether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
4.1: Claisen rearrangement;
DOI:10.1081/CAR-200067125
![[(1R,2R,3R,4R,6S,7R)-2,3-di(t-butyldimethylsilyloxy)-4-(t-butyldimethylsilyloxymethyl)bicyclo[4.1.0]hept-7-yl]methanol](/Databaselist/images/loading.webp)
