(2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester

Base Information

Chemical Name:(2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester
CAS No.:1338797-60-6
Molecular Formula:C₄₆H₆₂N₂O₁₁
Molecular Weight:819.005
Hs Code.:

Synonyms:(2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester

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Chemical Property of (2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester

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Technology Process of (2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester

There total 4 articles about (2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1338797-59-3
3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

: 1338797-60-6
(2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 2.5h;
DOI:10.1016/j.bmc.2011.07.040

Reference yield:

: 505-95-3
12-hydroxydodecanoic acid

: 1338797-60-6
(2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 60 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / methanol / 2.5 h / 20 °C

With dmap; toluene-4-sulfonic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.07.040

Reference yield:

: 3476-50-4
deacetylcolchicine

: 1338797-60-6
(2R,3S)-N-(tert-butoxycarbonyl)phenylisoserine 12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 60 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Inert atmosphere

3: toluene-4-sulfonic acid / methanol / 2.5 h / 20 °C

With dmap; toluene-4-sulfonic acid; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/j.bmc.2011.07.040