3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

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Chemical Name:3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate
CAS No.:1338797-59-3
Molecular Formula:C₅₄H₆₈N₂O₁₂
Molecular Weight:937.14
Hs Code.:

Synonyms:3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

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Chemical Property of 3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

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Technology Process of 3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

There total 3 articles about 3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1338797-58-2
N-(12-hydroxydodecanoyl)-N-deacetylcolchicine

: 196404-55-4
acide (4S,5R)-N-(tert-butoxycarbonyl)-2-(4-O-methoxyphenyl)-4-phenyl-5-oxazolidine carboxylique

: 1338797-59-3
3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.07.040

Reference yield:

: 505-95-3
12-hydroxydodecanoic acid

: 1338797-59-3
3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 60 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.bmc.2011.07.040

Reference yield:

: 3476-50-4
deacetylcolchicine

: 1338797-59-3
3-tert-butyl 5-[12-oxo-12-(N-deacetylcolchicin-7-N-yl)dodecyl] (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 60 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Inert atmosphere

With dmap; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.bmc.2011.07.040