2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole

Base Information

Chemical Name:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole
CAS No.:1392517-56-4
Molecular Formula:C₂₁H₁₉ClF₂N₄
Molecular Weight:400.858
Hs Code.:

Synonyms:2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole

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Chemical Property of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole

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Technology Process of 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole

There total 7 articles about 2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392517-54-2
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

: 1392517-56-4
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole

Guidance literature:: With iron; acetic acid; In ethanol; at 110 ℃; for 1h; Microwave irradiation;

Reference yield:

: 64248-56-2
1-bromo-2,6-difluorobenzene

: 1392517-56-4
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: acetic acid; iron / ethanol / 1 h / 110 °C / Microwave irradiation

With iron; sodium hydride; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 89466-07-9
4-amino-3-nitrophenylboronic acid

: 1392517-56-4
2-(5-tert-butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-5-(2,6-difluoro-phenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: acetic acid; iron / ethanol / 1 h / 110 °C / Microwave irradiation

With iron; sodium hydride; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil;