5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

Base Information

Chemical Name:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide
CAS No.:1392517-54-2
Molecular Formula:C₂₁H₁₉ClF₂N₄O₃
Molecular Weight:448.857
Hs Code.:

Synonyms:5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

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Chemical Property of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

There total 6 articles about 5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259026-54-4
2',6'-difluoro-3-nitro-[1,1'-biphenyl]-4-amine

: 286837-90-9
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carbonyl chloride

: 1392517-54-2
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

Guidance literature:: 2',6'-difluoro-3-nitro-[1,1'-biphenyl]-4-amine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h; Inert atmosphere;

5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carbonyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 64248-56-2
1-bromo-2,6-difluorobenzene

: 1392517-54-2
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 89466-07-9
4-amino-3-nitrophenylboronic acid

: 1392517-54-2
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid (2',6'-difluoro-3-nitro-biphenyl-4-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;