methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate

Base Information

Chemical Name:methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate
CAS No.:951790-43-5
Molecular Formula:C₁₇H₁₃ClF₃NO₃
Molecular Weight:371.743
Hs Code.:

Synonyms:methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate

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Chemical Property of methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate

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Technology Process of methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate

There total 2 articles about methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 850156-39-7
2-chloro-3-(trifluoromethyl)benzoyl chloride

: 15028-39-4,13226-98-7
L-2-phenylglycine methyl ester hydrochloride

: 951790-43-5
methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 39226-97-6
2-chloro-3-trifluoromethylbenzoic acid

: 951790-43-5
methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1.5 h / Heating / reflux

2: triethylamine / dichloromethane / 16 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

Reference yield:

: 951790-43-5
methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate

: 2-chloro-N-[(1S)-2-oxo-1-phenylethyl]-3-(trifluoromethyl)benzamide

Guidance literature:: methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 3h;

With methanol; In toluene; at -78 - 20 ℃;