850156-39-7

Basic information

• Product Name: 2-CHLORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: 2-CHLORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE;2-Chloro-3-(trifluoromethyl)benzoyl chloride 98%;2-Chloro-3-(trifluoromethyl)benzoylchloride98%;2-Chloro-3-(chlorocarbonyl)benzotrifluoride
• CAS NO: 850156-39-7
• Molecular Formula: C₈H₃Cl₂F₃O
• Molecular Weight: 243.01
• Mol File: 850156-39-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 224
• Flash Point: 101.4±27.3℃
• Appearance: /
• Density: 1.506±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.117mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 2-CHLORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(850156-39-7)
• EPA Substance Registry System: 2-CHLORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(850156-39-7)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 850156-39-7(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-(trifluoromethyl)benzoyl chloride is a chemical compound with the molecular formula C8H4Cl2F3O. It is a colorless, clear liquid with a pungent odor. 2-CHLORO-3-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is primarily used as an intermediate in the production of various pharmaceuticals and agrochemicals. It is also used in the manufacturing of dyes and pigments, as well as in the synthesis of other organic compounds. The presence of a trifluoromethyl group in this compound makes it highly reactive and useful in a wide range of chemical processes. However, it is important to handle this compound with care, as it is corrosive and may cause irritation to the skin, eyes, and respiratory system. Additionally, it may react violently with water and other substances, so it should be stored and handled according to strict safety guidelines.

InChI:InChI=1/C8H3Cl2F3O/c9-6-2-4(7(10)14)1-5(3-6)8(11,12)13/h1-3H

Upstream product

• 39226-97-6 2-chloro-3-trifluoromethylbenzoic acid 

Downstream Products

• 951790-43-5 methyl (2S)-({[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}amino)(phenyl)ethanoate 
• 1190739-34-4 C₂₁H₂₈ClF₃N₂O₃ 
• 1239322-51-0 2-chloro-N-((2-methyl-3-oxo-2-azabicyclo[2.2.2]octan-1-yl)(pyridin-3-yl)methyl)-3-(trifluoromethyl)-benzamide 
• 1239321-28-8 2-chloro-N-((2-methyl-2-azabicyclo[2.2.2]octan-1-yl)(4-(propylsulfonyl)phenyl)methyl)-3-(trifluoromethyl)benzamide 
• 1239321-29-9 2-chloro-N-((3-methoxyphenyl)(2-methyl-2-azabicyclo[2.2.2]octan-1-yl)methyl)-3-(trifluoromethyl)benzamide 
• 1239321-34-6 2-chloro-N-(furan-2-yl(2-methyl-2-azabicyclo[2.2.2]octan-1-yl)methyl)-3-(trifluoromethyl)benzamide 
• 62584-32-1 2-chloro-3-trifluoromethylbenzonitrile 
• 899431-48-2 5-(2-chloro-3-trifluoromethylphenyl)-1H-tetrazole 
• 39959-94-9 2-chloro-3-trifluoromethylbenzamide 

Relevant articles and documents

INHIBITING USP36

The present disclosure is directed to compounds of formulas (I) - (VI), which are useful as modulators of USP36. The compounds are further useful in the inhibition of USP36 and the treatment of diseases or disorders associated with the inhibition of USP36

Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor

The synthesis and SAR of a series of 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridine P2X7 antagonists are described. Addressing P2X7 affinity and liver microsomal stability issues encountered with this template afforded methyl substituted 4,5,6,7-tetrahydro-imidazo[4,5-c]pyridines ultimately leading to the identification of 1 (JNJ 54166060). 1 is a potent P2X7 antagonist with an ED50 = 2.3 mg/kg in rats, high oral bioavailability and low-moderate clearance in preclinical species, acceptable safety margins in rats, and a predicted human dose of 120 mg of QD. Additionally, 1 possesses a unique CYP profile and was found to be a regioselective inhibitor of midazolam CYP3A metabolism.

P2X7 MODULATORS

The present invention is directed to a compound of Formula (I) The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.