methyl cis-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Base Information

Chemical Name:methyl cis-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
CAS No.:1433219-52-3
Molecular Formula:C₂₀H₂₀F₃NO₄
Molecular Weight:395.378
Hs Code.:

Synonyms:methyl cis-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

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Chemical Property of methyl cis-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

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Technology Process of methyl cis-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

There total 1 articles about methyl cis-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 78083-80-4
(S)-2-amino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester

: 1433219-49-8
methyl trans-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 1433219-52-3
methyl cis-(1S,3S)-6,7-dimethoxy-1-(4-trifluoromethylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

Guidance literature:: 4-Trifluoromethylbenzaldehyde; (S)-2-amino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester; In dichloromethane; at 0 - 20 ℃; Molecular sieve; Inert atmosphere;

With trifluoroacetic acid; diastereoselective reaction; Reflux; Inert atmosphere;
DOI:10.1002/chem.201202615