(E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide

Base Information

• Chemical Name: (E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide
• CAS No.: 375846-19-8
• Molecular Formula: C₂₂H₂₃FN₂O₂
• Molecular Weight: 366.435

Synonyms:(E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide

Chemical Property of (E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide

Chemical Property:

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Technology Process of (E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide

There total 2 articles about (E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate (124931-12-0) + 3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-carboxaldehyde (101125-34-2) → (E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide (375846-19-8)

Guidance literature:

With sodium; In tetrahydrofuran; water; pentane;

Reference yield:

2-bromo-3-(4-fluorophenyl)-1-isopropyl-1H-indole (375846-18-7) + N-methoxy-N-methylacrylamide (193634-77-4) → (E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide (375846-19-8)

Guidance literature:

With nitrogen; sodium acetate; In water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

(E)-3-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-N-methoxy-N-methylacrylamide (375846-19-8) + carbon dioxide (124-38-9,18923-20-1) → (E)-5-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3-oxopent-4-enoic Acid Ethyl Ester (375846-20-1)

Guidance literature:

With n-butyllithium; ammonium chloride; sodium; In tetrahydrofuran; ethanol; hexane; ethyl acetate; toluene;

upstream raw materials:

diethyl (N-methoxy-N-methylcarbamoylmethyl)phosphonate

3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indole-2-carboxaldehyde

2-bromo-3-(4-fluorophenyl)-1-isopropyl-1H-indole

N-methoxy-N-methylacrylamide

Downstream raw materials:

(E)-5-[3-(4-Fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3-oxopent-4-enoic Acid Ethyl Ester

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