(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide

Base Information

Chemical Name:(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide
CAS No.:1357917-74-8
Molecular Formula:C₁₆H₁₉N₃O₄
Molecular Weight:317.345
Hs Code.:

Synonyms:(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide

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Chemical Property of (1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide

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Technology Process of (1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide

There total 2 articles about (1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 930-88-1
N-methylmaleimide

: 154780-68-4
2-benzylideneamino-N-methyl-N-methoxyacetamide

: 1357917-74-8
(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide

Guidance literature:: With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine; In tetrahydrofuran; at 20 ℃; for 17h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c2cc17149j

Reference yield:

: 100-52-7
benzaldehyde

: 1357917-74-8
(1R,3S,3aS,6aR)-5-methyl-4,6-dioxo-3-phenyl octahydropyrrolo[3,4-c]pyrrole-1-(N-methyl,N-methoxy)carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / dichloromethane / 40 °C / Inert atmosphere

2: (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; triethylamine / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; magnesium sulfate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cc17149j