(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione
CAS No.:1213254-35-3
Molecular Formula:C₂₄H₃₀FN₅O₄
Molecular Weight:471.532
Hs Code.:

Synonyms:(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Property of (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

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Technology Process of (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

There total 10 articles about (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1213255-73-2
1-(hex-5-ynyl)pyrimidine-2,4(1H,3H)-dione

: 1213256-11-1
(S)-1-azido-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)butan-2-ol

: 1213254-35-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In 1,4-dioxane; at 80 ℃;
DOI:10.1021/jm3004174

Reference yield:

: C₁₇H₁₆N₂O₃

: 1213254-35-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: methylamine / methanol / 1 h / 20 °C

2: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); methylamine; In 1,4-dioxane; methanol;
DOI:10.1021/jm3004174

Reference yield:

: 1204659-44-8
1-(3-(cyclopropylmethoxy)-4-fluorophenyl)propan-1-one

: 1213254-35-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: 12 h / 0 - 20 °C

2.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 20 °C

4.1: sodium azide / dichloromethane; N,N-dimethyl-formamide / 12 h / 90 °C

5.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C

With sodium azide; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1.2: Wittig reaction;
DOI:10.1021/jm3004174