(S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

Base Information

Chemical Name:(S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate
CAS No.:1350514-90-7
Molecular Formula:C₁₅H₂₁FO₅S
Molecular Weight:332.393
Hs Code.:

Synonyms:(S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

Suppliers and Price of (S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

There total 13 articles about (S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1213256-09-7
(S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)butane-1,2-diol

: 124-63-0
methanesulfonyl chloride

: 1350514-90-7
(S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1252898-90-0
3-(cyclopropylmethoxy)-4-fluorobenzoic acid

: 1350514-90-7
(S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 3.17 h / 30 °C / Inert atmosphere

3.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 12 h / 0 - 20 °C

4.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C

5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 20 °C

With AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; benzotriazol-1-ol; methanesulfonyl chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3.2: Wittig reaction;
DOI:10.1021/jm3004174

Reference yield:

: 1204659-56-2
3-(cyclopropylmethoxy)-4-fluoro-N-methoxy-N-methylbenzamide

: 1350514-90-7
(S)-2-(3-(cyclopropylmethoxy)-4-fluorophenyl)-2-hydroxybutyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 3.17 h / 30 °C / Inert atmosphere

2.1: Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 12 h / 0 - 20 °C

3.1: AD-mix-α / water; tert-butyl alcohol / 3 h / 0 °C

4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.5 h / 20 °C

With AD-mix-α; Methyltriphenylphosphonium bromide; sodium hexamethyldisilazane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; tert-butyl alcohol; 2.2: Wittig reaction;
DOI:10.1021/jm3004174