1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

Base Information

Chemical Name:1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene
CAS No.:111026-03-0
Molecular Formula:C₂₉H₄₈O₂Si
Molecular Weight:456.784
Hs Code.:

1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benz<f>indene

Synonyms:1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

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Chemical Property of 1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

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Technology Process of 1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

There total 4 articles about 1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.9%

: 111026-01-8,111026-02-9
Toluene-4-sulfonic acid (R)-3-[(1R,2R,3aS,9aS)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-1-yl]-1-cyclohexyl-propyl ester

: 111026-03-0
1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1021/jo00234a016

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 111026-03-0
1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / imidazole / tetrahydrofuran / 96 h / 0 - 20 °C

2: 0.33 g / pyridine, water / 24.5 h / 0 - 20 °C

3: 78.9 percent / lithium aluminum hydride / diethyl ether / 24 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; water; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00234a016

Reference yield:

: 99511-98-5
15-cyclohexyl-9-deoxy-13,14-dihydro-2',9α-methano-3-oxa-1,4,5,6,16,17,18,19,20-nonanor-3,7-(1',3'-inter-phenylene)-PGF1

: 111026-03-0
1(R)-(3-cyclohexylpropyl)-2,3,3a,4,9,9a-hexahydro-2(R)-<(tert-butyldimethylsilyl)oxy>-5-methoxy-(3aS,9aS)-1H-benzindene

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / imidazole / tetrahydrofuran / 96 h / 0 - 20 °C

2: 0.33 g / pyridine, water / 24.5 h / 0 - 20 °C

3: 78.9 percent / lithium aluminum hydride / diethyl ether / 24 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; water; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jo00234a016