(+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Base Information

Chemical Name:(+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester
CAS No.:151105-96-3
Molecular Formula:C₂₇H₂₇F₂NO₄
Molecular Weight:467.512
Hs Code.:

Synonyms:(+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Suppliers and Price of (+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

There total 16 articles about (+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-2-propenol

: 151105-96-3
(+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 20 percent / MnO₂ / CH₂Cl₂ / 1 h / 20 °C

2: 81 percent / I₂ / CCl₄ / 42 h / Irradiation

3: 1.) NaH, n-BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, from 2 deg C to 20 deg C, 45 min

With manganese(IV) oxide; n-butyllithium; iodine; sodium hydride; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00075a021

Reference yield:

: 115672-63-4
1-(4-fluorophenyl)-5-methyl-2-(2-pyridyl)-1,4-hexanedione

: 151105-96-3
(+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / ammonium acetate, AcOH / Heating

2: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, 20 deg C, 1 h

3: DIBAL-H / toluene / -65 - -5 °C

4: 20 percent / MnO₂ / CH₂Cl₂ / 1 h / 20 °C

5: 81 percent / I₂ / CCl₄ / 42 h / Irradiation

6: 1.) NaH, n-BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, from 2 deg C to 20 deg C, 45 min

With ammonium acetate; manganese(IV) oxide; n-butyllithium; iodine; sodium hydride; diisobutylaluminium hydride; acetic acid; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm00075a021

Reference yield:

: 151105-83-8
2-(4-fluorophenyl)-5-(1-methylethyl)-3-(2-pyridyl)-1H-pyrrole

: 151105-96-3
(+/-)-(E)-7-<2,3-bis(4-fluorophenyl)-5-(1-methylethyl)-1H-pyrrol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 10 min, 2.) DMF, 20 deg C, 1 h

2: DIBAL-H / toluene / -65 - -5 °C

3: 20 percent / MnO₂ / CH₂Cl₂ / 1 h / 20 °C

4: 81 percent / I₂ / CCl₄ / 42 h / Irradiation

5: 1.) NaH, n-BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, from 2 deg C to 20 deg C, 45 min

With manganese(IV) oxide; n-butyllithium; iodine; sodium hydride; diisobutylaluminium hydride; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm00075a021