2-(Diethylamino)ethyl 9-hydroxy-9-fluorenecarboxylate

Base Information

• Chemical Name: 2-(Diethylamino)ethyl 9-hydroxy-9-fluorenecarboxylate
• CAS No.: 24539-81-9
• Molecular Formula: C₂₀H₂₃NO₃
• Molecular Weight: 325.408
• DSSTox Substance ID: DTXSID80179283
• Nikkaji Number: J69.713C
• Wikidata: Q83049793
• Mol file: 24539-81-9.mol

Synonyms:BRN 0928642;9-FLOURENECARBOXYLIC ACID, 9-HYDROXY-, 2-(DIETHYLAMINO)ETHYL ESTER;2-(Diethylamino)ethyl 9-hydroxy-9-fluorenecarboxylate;24539-81-9;9-Hydroxy-9-fluorenecarboxylic acid 2-(diethylamino)ethyl ester;2-(diethylamino)ethyl 9-hydroxy-9h-fluorene-9-carboxylate hydrochloride;2-diethylaminoethyl 9-hydroxyfluorene-9-carboxylate;DTXSID80179283;AKOS040766809;LS-69222;9-Hydroxy-9H-fluorene-9-carboxylic acid 2-(diethylamino)ethyl ester;9H-Fluorene-9-carboxylic acid, 9-hydroxy-, 2-(diethylamino)ethyl ester

Chemical Property of 2-(Diethylamino)ethyl 9-hydroxy-9-fluorenecarboxylate

Chemical Property:

• Boiling Point: 420.7°Cat760mmHg
• Flash Point: 208.2°C
• PSA: 49.77000
• Density: 1.2g/cm³
• LogP: 2.78790
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 325.16779360
• Heavy Atom Count: 24
• Complexity: 413

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCOC(=O)C1(C2=CC=CC=C2C3=CC=CC=C31)O

Technology Process of 2-(Diethylamino)ethyl 9-hydroxy-9-fluorenecarboxylate

There total 5 articles about 2-(Diethylamino)ethyl 9-hydroxy-9-fluorenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-hydroxy-9-fluorene carboxylic acid (467-69-6) + 2-(diethylamino)ethyl chloride (100-35-6) → 9-hydroxy-fluorene-9-carboxylic acid-(2-diethylamino-ethyl ester) (24539-81-9)

Guidance literature:

With isopropyl alcohol;

DOI:10.1021/ja01242a036

Reference yield:

9-hydroxy-9-fluorene carboxylic acid (467-69-6) + 2-(Diethylamino)ethanol (100-37-8) → 9-hydroxy-fluorene-9-carboxylic acid-(2-diethylamino-ethyl ester) (24539-81-9)

Guidance literature:

With hydrogenchloride;

Reference yield:

9-bromo-fluorene-9-carbonyl bromide (861571-57-5) + 2-(Diethylamino)ethanol (100-37-8) → 9-hydroxy-fluorene-9-carboxylic acid-(2-diethylamino-ethyl ester) (24539-81-9)

Guidance literature:

With benzene; Erwaermen des Reaktionsprodukts mit Silberacetat und Essigsaeure;

upstream raw materials:

9-hydroxy-9-fluorene carboxylic acid

2-(diethylamino)ethyl chloride

2-(Diethylamino)ethanol

9-bromo-fluorene-9-carbonyl bromide

Refernces

• 1、 Bowden,Young. "Structure-activity relations. I. Series of antagonists of acetylcholine and histamine at the postganglionic receptors.". . p. 225,226. Retrieved 2007/10/05.