Technology Process of 4-(2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride
There total 4 articles about 4-(2'-nitrobenzyloxycarbonyloxy)-3,5-dimethylbenzyl fluoride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
diethyl ether;
for 0.5h;
DOI:10.1021/jo991085t
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / potassium carbonate / dimethylformamide / 17 h / 20 °C
2: 96 percent / sodium borohydride / ethanol / 1 h / 20 °C
3: 48 percent / diethylaminosulfur trifluoride / diethyl ether / 0.5 h
With
sodium tetrahydroborate; diethylamino-sulfur trifluoride; potassium carbonate;
In
diethyl ether; ethanol; N,N-dimethyl-formamide;
1: Acylation / 2: Reduction / 3: Fluorination;
DOI:10.1021/jo991085t
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99 percent / toluene; tetrahydrofuran / 21 h
2: 80 percent / potassium carbonate / dimethylformamide / 17 h / 20 °C
3: 96 percent / sodium borohydride / ethanol / 1 h / 20 °C
4: 48 percent / diethylaminosulfur trifluoride / diethyl ether / 0.5 h
With
sodium tetrahydroborate; diethylamino-sulfur trifluoride; potassium carbonate;
In
tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide; toluene;
1: Esterification / 2: Acylation / 3: Reduction / 4: Fluorination;
DOI:10.1021/jo991085t
