42854-99-9Relevant academic research and scientific papers
A caged substrate peptide for matrix metalloproteinases
Decaneto, Elena,Abbruzzetti, Stefania,Heise, Inge,Lubitz, Wolfgang,Viappiani, Cristiano,Knipp, Markus
, p. 300 - 307 (2015)
Based on the widely applied fluorogenic peptide FS-6 (Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2; Mca = methoxycoumarin-4-acetyl; Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl) a caged substrate peptide Ac-Lys-Pro-Leu-Gly-Lys-Lys-Ala-Arg-NH
Photoactivatable Fluorophore for Stimulated Emission Depletion (STED) Microscopy and Bioconjugation Technique for Hydrophobic Labels
Weber, Michael,Khan, Taukeer A.,Patalag, Lukas J.,Bossi, Mariano,Leutenegger, Marcel,Belov, Vladimir N.,Hell, Stefan W.
supporting information, p. 451 - 458 (2020/11/30)
The use of photoactivatable dyes in STED microscopy has so far been limited by two-photon activation through the STED beam and by the fact that photoactivatable dyes are poorly solvable in water. Herein, we report ONB-2SiR, a fluorophore that can be both
Polysilsesquioxane-based nano drug loading system capable of controllably releasing drugs through light triggering and preparation method thereof
-
Paragraph 0072-0074; 0077; 0082-0084; 0087; 0092-0094; 0097, (2020/08/22)
The invention relates to a light-triggered polysilsesquioxane-based nano drug loading system capable of controllably releasing drugs and a preparation method thereof. An o-nitrobenzyl bridged polysilsesquioxane nano-carrier with photoresponsive charge rev
Trigger-responsive chain-shattering polymers
-
Page/Page column 30, (2017/04/29)
Disclosed are polymers containing a backbone comprising alternating N-protected hydroxymethylaniline units (“spacer”) and linker units.
UV-responsive degradable polymers derived from 1-(4-aminophenyl) ethane-1,2-diol
Ma, Liang,Baumgartner, Ryan,Zhang, Yanfeng,Song, Ziyuan,Cai, Kaimin,Cheng, Jianjun
, p. 1161 - 1168 (2015/03/31)
A UV-responsive polymer was prepared via condensation polymerization of 2-nitrobenzyl(4-(1,2-dihydroxyethyl)phenyl)carbamate and azalaic acid dichloride. When the polymer was irradiated with UV light, the nitrobenzyl urethane protecting group was removed and the deprotected aniline underwent spontaneous 1,6-elimination reactions, resulting in degradation of the polymer. Nanoparticles with encapsulated Nile Red were formulated with the degradable polymer and triggered burst release of Nile Red was observed when the nanoparticles were irradiated by UV light.
Chain-shattering polymeric therapeutics with on-demand drug-release capability
Zhang, Yanfeng,Yin, Qian,Yin, Lichen,Ma, Liang,Tang, Li,Cheng, Jianjun
supporting information, p. 6435 - 6439 (2013/07/27)
Trigger happy: Trigger-responsive chain-shattering polymeric therapeutics (CSPTs) were prepared by condensation polymerization of a UV- or hydrogen peroxide-responsive domain and a drug as co-monomers. Drug release can be started and stopped by starting and stopping the trigger treatment. Chemotherapeutic-containing CSPTs showed trigger-responsive in vitro and in vivo antitumor efficacy. Copyright
Light-triggered charge reversal of organic-silica hybrid nanoparticles
Hu, Li-Chih,Yonamine, Yusuke,Lee, Shih-Hui,Van Der Veer, Wytze E.,Shea, Kenneth J.
supporting information; experimental part, p. 11072 - 11075 (2012/08/28)
A functional nanoparticle with light-triggered charge reversal based on a protected amine-bridged polysilsesquioxane was designed. An emulsion- and amine-free sol-gel synthesis was developed to prepare uniform nanospheres. Photolysis of suspensions of these nanoparticles results in a reversal of the χ potential. This behavior has been used to trigger nanoparticle self-assembly, nanocomposite hydrogel formation, and nanoparticle release, showing the potential of this material in nanoscale manipulation and nanoparticle therapy.
De Novo design and utilization of photolabile caged substrates as probes of hydrogen tunneling with horse liver alcohol dehydrogenase at sub-zero temperatures: A cautionary note
Tsai, Shiou-Chuan,Klinman, Judith P.
, p. 172 - 190 (2007/10/03)
In order to understand the influence of protein dynamics on enzyme catalysis and hydrogen tunneling, the horse liver alcohol dehydrogenase (HLADH) catalyzed oxidation of benzyl alcohol was studied at sub-zero temperatures. Previous work showed that wild t
Hydrolytic stabilization of protected p-hydroxybenzyl halides designed as latent quinone methide precursors
Dyer, Robert G.,Turnbull, Kenneth D.
, p. 7988 - 7995 (2007/10/03)
The hydrolysis rates of a series of protected p-hydroxybenzyl halides designed to generate a p-quinone methide through 1,6-elimination following photolytic deprotection have been investigated in order to optimize hydrolytic stability. A number of p-hydroxybenzyl halides containing an ether or carbonate-linked photolabile hydroxy protecting group and a fluoride, chloride, or bromide benzylic leaving group have been synthesized. The hydrolysis rates of these derivatives in different water acetonitrile mixtures and temperatures have been determined. The hydrolysis half-life of the benzyl bromide with the p-hydroxy protected as the carbonate-linked α- methylnitroveratryl (18c) is more than 750 times that of the ether-linked analogue (16c). These studies afford a Hammett σp+ of +0.28 for the carbonate-linked derivatives compared to a σ+ of -0.39 for the ether-linked derivatives. The theoretical hydrolysis half-life of the most stable benzyl fluoride in 100% water was sufficiently long so as to preclude extrapolation, while the chloride was approximately 50 h, and even the bromide was estimated to be nearly 5 h.
Synthesis of caged peptides using caged lysine: Application to the synthesis of caged AIP, a highly specific inhibitor of calmodulin-dependent protein kinase II
Tatsu, Yoshiro,Shigeri, Yasushi,Ishida, Atsuhiko,Kameshita, Isamu,Fujisawa, Hitoshi,Yumoto, Noboru
, p. 1093 - 1096 (2007/10/03)
N(α)-Fmoc-N(ε)-(2-nitrobenzyloxycarbonyl)-lysine has been prepared and used in the solid-phase synthesis of caged peptides. The synthesized caged AIP (cagedKcageKALRRQEAVDAL) showed characteristics required for caged peptides including a significantly red
