ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Base Information

Chemical Name:ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate
CAS No.:1446865-01-5
Molecular Formula:C₂₈H₂₅ClO₄
Molecular Weight:460.957
Hs Code.:

Synonyms:ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

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Chemical Property of ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

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Technology Process of ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

There total 4 articles about ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1446864-82-9
ethyl 4-(4-chlorophenyl)-2-iodo-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

: 536-74-3
phenylacetylene

: 1446865-01-5
ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Guidance literature:: With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In ethanol; at 60 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.05.014

Reference yield:

: 126-81-8
dimedone

: 1446865-01-5
ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / ethanol

1.2: 80 °C

2.1: copper(l) iodide; tert.-butylnitrite / acetonitrile / 2 h / 0 °C

3.1: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 1 h / 60 °C / Inert atmosphere

With dmap; copper(l) iodide; tert.-butylnitrite; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In ethanol; acetonitrile; 2.1: |Sandmeyer Reaction / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.05.014

Reference yield:

: 107752-95-4
ethyl 2-amino-7,7-dimethyl-5-oxo-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

: 1446865-01-5
ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tert.-butylnitrite / acetonitrile / 2 h / 0 °C

2: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 1 h / 60 °C / Inert atmosphere

With copper(l) iodide; tert.-butylnitrite; palladium 10% on activated carbon; triethylamine; triphenylphosphine; In ethanol; acetonitrile; 1: |Sandmeyer Reaction / 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.05.014