10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

Base Information

Chemical Name:10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione
CAS No.:1446865-31-1
Molecular Formula:C₂₆H₂₀ClIO₄
Molecular Weight:558.8
Hs Code.:

Synonyms:10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

Suppliers and Price of 10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

There total 5 articles about 10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1446865-01-5
ethyl 4-(4-chlorophenyl)-7,7-dimethyl-5-oxo-2-(phenylethynyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

: 1446865-31-1
10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

Guidance literature:: With iodine; In dichloromethane; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.05.014

Reference yield:

: 107752-95-4
ethyl 2-amino-7,7-dimethyl-5-oxo-4-(4-chlorophenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate

: 1446865-31-1
10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; tert.-butylnitrite / acetonitrile / 2 h / 0 °C

2: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 1 h / 60 °C / Inert atmosphere

3: iodine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; tert.-butylnitrite; palladium 10% on activated carbon; iodine; triethylamine; triphenylphosphine; In ethanol; dichloromethane; acetonitrile; 1: |Sandmeyer Reaction / 2: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.05.014

Reference yield:

: 126-81-8
dimedone

: 1446865-31-1
10-(4-chlorophenyl)-4-iodo-7,7-dimethyl-3-phenyl-7,8-dihydropyrano[4,3-b]chromene-1,9(6H,10H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / ethanol

1.2: 80 °C

2.1: copper(l) iodide; tert.-butylnitrite / acetonitrile / 2 h / 0 °C

3.1: copper(l) iodide; triphenylphosphine; palladium 10% on activated carbon; triethylamine / ethanol / 1 h / 60 °C / Inert atmosphere

4.1: iodine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; tert.-butylnitrite; palladium 10% on activated carbon; iodine; triethylamine; triphenylphosphine; In ethanol; dichloromethane; acetonitrile; 2.1: |Sandmeyer Reaction / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2013.05.014