Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Base Information

Chemical Name:Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide
CAS No.:724733-56-6
Molecular Formula:C₃₂H₄₅BrN₆O₇
Molecular Weight:705.649
Hs Code.:

Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Synonyms:Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

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Chemical Property of Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

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Technology Process of Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

There total 12 articles about Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 38689-32-6
(S)-2-((S)-2-aminopropanoylamino)-4-methylpentanoic acid amide

: 724733-75-9
(S)-3-methyl-2-[(1-pyridin-2-ylmethanoyl)amino]butyric acid

: 724733-51-1
(3S,4S)-4-azido-5-(4-bromobenzyloxy)-3-hydroxypentanoic acid methyl ester

: 724733-56-6
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

: Pyridine-2-carboxylic acid ((R)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multistep reaction;
DOI:10.1021/jm031106i

Reference yield:

: 687-51-4,13079-20-4,13366-40-0,15893-47-7
H-L-Leu-NH₂

: 724733-56-6
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-7-azabenzotriazole; 1,8-bis(N,N-dimethylamino)naphthalene; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 0 - 20 °C

2: 100 percent / H₂ / Pd/C / aq. ethanol / 1.5 h / atmospheric pressure

With 1-hydroxy-7-aza-benzotriazole; hydrogen; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm031106i

Reference yield:

: 18323-56-3
Z-(S)-Ala-(S)-Leu-NH₂

: 724733-56-6
Pyridine-2-carboxylic acid ((S)-1-{(1S,2S)-1-(4-bromo-benzyloxymethyl)-3-[(S)-1-((S)-1-carbamoyl-3-methyl-butylcarbamoyl)-ethylcarbamoyl]-2-hydroxy-propylcarbamoyl}-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/C / aq. ethanol / 1.5 h / atmospheric pressure

With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm031106i