methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate

Base Information

• Chemical Name: methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate
• CAS No.: 240420-34-2
• Molecular Formula: C₁₇H₂₅NO₅
• Molecular Weight: 323.389
• Mol file: 240420-34-2.mol

Synonyms:methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate

Chemical Property of methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate

There total 6 articles about methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate (115378-31-9) → methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate (240420-34-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 9-BBN-H / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: 71 percent / K₃PO₄ / PdCl₂(dppf)*CHCl₃ / tetrahydrofuran; H₂O; dimethylformamide

2.1: Jones reagent / acetone / 5 h / 0 - 20 °C

3.1: 34 mg / ethyl acetate; diethyl ether / 0.5 h / 0 °C

With 9-borabicyclo[3.3.1]nonane dimer; jones reagent; In tetrahydrofuran; diethyl ether; ethyl acetate; acetone; 1.2: Suzuki coupling / 2.1: Jones oxidation-cleavage;

DOI:10.1021/jo010865a

Reference yield:

tert-butyl (4R)-4-[2-(4-methoxyphenyl)ethyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (240420-43-3) → methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate (240420-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones reagent / acetone / 5 h / 0 - 20 °C

2: 34 mg / ethyl acetate; diethyl ether / 0.5 h / 0 °C

With jones reagent; In diethyl ether; ethyl acetate; acetone; 1: Jones oxidation-cleavage;

DOI:10.1021/jo010865a

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-(tert-butyloxycarbonylamino)-4-(4-methoxyphenyl)butanoic acid → methyl (2R)-2-[(tert-butoxycarbonyl)amino]-4-(4-methoxyphenyl)butanoate (240420-34-2)

Guidance literature:

In diethyl ether;

DOI:10.1016/S0040-4039(99)00997-1

upstream raw materials:

diazomethane

para-iodoanisole

tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate

tert-butyl (4R)-4-[2-(4-methoxyphenyl)ethyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate