Technology Process of methyl (R)-2-(2-methoxyphenylamino)-6-phenyl-2-(trifluoromethyl)hex-3-ynoate
There total 3 articles about methyl (R)-2-(2-methoxyphenylamino)-6-phenyl-2-(trifluoromethyl)hex-3-ynoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-Phenyl-1-butyne;
With
dimethyl zinc(II);
In
toluene;
at 20 ℃;
for 1h;
Inert atmosphere;
With
(R)-3,3’-bis(trimethylsilyl)-[1,1’-binaphthalene]-2,2’-diol;
In
toluene;
at 20 ℃;
for 2.5h;
Inert atmosphere;
methyl 3,3,3-trifluoro-2-(2-methoxyphenylimino)propanoate;
In
toluene;
at 20 ℃;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1039/c1cc10403a
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triphenylphosphine / tetrahydrofuran / 2 h / Reflux
1.2: Reflux
2.1: dimethyl zinc(II) / toluene / 1 h / 20 °C / Inert atmosphere
2.2: 2.5 h / 20 °C / Inert atmosphere
2.3: 20 °C / Inert atmosphere
With
dimethyl zinc(II); triphenylphosphine;
In
tetrahydrofuran; toluene;
DOI:10.1039/c1cc10403a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite / water / 0 - 20 °C
1.2: 20 °C
2.1: triphenylphosphine / tetrahydrofuran / 2 h / Reflux
2.2: Reflux
3.1: dimethyl zinc(II) / toluene / 1 h / 20 °C / Inert atmosphere
3.2: 2.5 h / 20 °C / Inert atmosphere
3.3: 20 °C / Inert atmosphere
With
hydrogenchloride; dimethyl zinc(II); triphenylphosphine; sodium nitrite;
In
tetrahydrofuran; water; toluene;
DOI:10.1039/c1cc10403a