3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide

Base Information

Chemical Name:3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide
CAS No.:1452182-73-8
Molecular Formula:C₂₃H₂₂FN₅O₃S
Molecular Weight:467.524
Hs Code.:

Synonyms:3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide

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Chemical Property of 3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide

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Technology Process of 3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide

There total 4 articles about 3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110-91-8,99108-56-2
morpholine

: 1452183-86-6
4-bromo-3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)benzenesulfonamide

: 1452182-73-8
3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate monohydrate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; at 90 ℃; for 4.08h; Inert atmosphere;

Reference yield:

: 611-34-7,146614-41-7
5-Aminoquinoline

: 1452182-73-8
3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 0.17 h / 0 °C

1.2: 1.17 h / 0 °C

1.3: 1.25 h / 0 - 80 °C

2.1: ethanol; water / 2 h / 60 °C

3.1: pyridine / 4 h / 20 - 80 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium phosphate monohydrate / N,N-dimethyl-formamide / 4.08 h / 90 °C / Inert atmosphere

With pyridine; hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate monohydrate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 15793-79-0
quinolin-5-yl-hydrazine

: 1452182-73-8
3-fluoro-N-(3-methyl-1-(quinolin-5-yl)-1H-pyrazol-5-yl)-4-morpholinobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; water / 2 h / 60 °C

2: pyridine / 4 h / 20 - 80 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium phosphate monohydrate / N,N-dimethyl-formamide / 4.08 h / 90 °C / Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate monohydrate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; N,N-dimethyl-formamide;