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5-hydrazinylquinoline, also known as 5-Aminoquinoline or 5-AQ, is a chemical compound with the molecular formula C9H8N4. It is a derivative of quinoline and contains a hydrazine functional group, which makes it a potential building block for the synthesis of various organic compounds. This versatile compound is characterized by its unique chemical properties and potential applications in various fields, including pharmaceuticals, chemical, and biological research.

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  • 15793-79-0 Structure
  • Basic information

    1. Product Name: 5-hydrazinylquinoline
    2. Synonyms: 5-hydrazinylquinoline
    3. CAS NO:15793-79-0
    4. Molecular Formula: C9H9N3
    5. Molecular Weight: 159.18786
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 15793-79-0.mol
  • Chemical Properties

    1. Melting Point: 163 °C(Solv: benzene (71-43-2))
    2. Boiling Point: 381.4±15.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.290±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 5.48±0.12(Predicted)
    10. CAS DataBase Reference: 5-hydrazinylquinoline(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-hydrazinylquinoline(15793-79-0)
    12. EPA Substance Registry System: 5-hydrazinylquinoline(15793-79-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 15793-79-0(Hazardous Substances Data)

15793-79-0 Usage

Uses

Used in Pharmaceutical Industry:
5-hydrazinylquinoline is used as a precursor in the synthesis of antimalarial drugs for its potential to contribute to the development of new treatments against malaria. Its unique chemical structure allows for the creation of compounds that can target and combat the Plasmodium parasites responsible for the disease.
Used in Chemical Research:
5-hydrazinylquinoline serves as a valuable building block for the synthesis of a wide range of organic compounds. Its presence in various chemical reactions can lead to the discovery of new compounds with diverse applications, enhancing the scope of chemical research and development.
Used in Biological Research:
Due to its unique chemical properties, 5-hydrazinylquinoline is utilized in biological research to explore its interactions with biological systems. This can include studying its effects on cellular processes, its potential as a therapeutic agent, or its use in the development of diagnostic tools.

Check Digit Verification of cas no

The CAS Registry Mumber 15793-79-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,7,9 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 15793-79:
(7*1)+(6*5)+(5*7)+(4*9)+(3*3)+(2*7)+(1*9)=140
140 % 10 = 0
So 15793-79-0 is a valid CAS Registry Number.

15793-79-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name quinolin-5-ylhydrazine

1.2 Other means of identification

Product number -
Other names 5-hydrazinoquinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15793-79-0 SDS

15793-79-0Relevant articles and documents

Discovery of zoniporide: A potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility

Guzman-Perez, Angel,Wester, Ronald T.,Allen, Mary C.,Brown, Janice A.,Buchholz, Allan R.,Cook, Ewell R.,Day, Wesley W.,Hamanaka, Ernest S.,Kennedy, Scott P.,Knight, Delvin R.,Kowalczyk, Paul J.,Marala, Ravi B.,Mularski, Christian J.,Novomisle, William A.,Ruggeri, Roger B.,Tracey,Hill, Roger J.

, p. 803 - 807 (2001)

Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of this compound are presented. The potency and selectivity of zoniporide may be due to the conformation that the molecule adopts due to the presence of a cyclopropyl and a 5-quinolinyl substituent on the central pyrazole ring of the molecule.

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

-

Paragraph 0133; 0134, (2018/02/28)

Compounds are provided that act as potent antagonists of the CCR(9) receptor for treating Sjogren's syndrome. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

-

Paragraph 0684, (2018/04/17)

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

-

Paragraph 1149; 1150, (2018/07/05)

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

-

Paragraph 0136; 0137, (2013/09/12)

Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9). The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR(9)-mediated diseases, and as controls in assays for the identification of CCR(9) antagonists.

Study of synthesis of some pyrroloquinolines, pyrroloisoquinolines, pyridocarbazoles and their derivatives

Fathalipour, Soghra,Shahrokhnia, Nazila,Afghan, Arash,Baradarani, Mehdi M.

experimental part, p. 5808 - 5814 (2010/12/24)

The new isomers of pyrroloquinolines, pyrroloisoquinolines and pyridocarbazoles have been synthesized from the hydrazone of methylisopropylketone, 2-methylcyclohexanone, 5 and 8-quinolylhydrazine and 5-isoquinolylhydrazine by ring closure in AcOH at reflux in excellent yields. The methiodide of pyrroloisoquinoline and pyridocarbazole were reduced with NaBH4 at room temperature to produce corresponding hexahydropyrroloisoquinoline and decahydropyridoisoquinoline in good yields.

Ligand-Receptor Interactions via Hydrogen-Bond Formation. Synthesis and Pharmacological Evaluation of Pyrrolo and Pyrido Analogues of the Cardiotonic Agent 7-Hydroxycyclindole

Dionne, Gervais,Humber, Leslie G.,Asselin, Andre,McQuillan, Juanita,Treasurywala, Adi M.

, p. 1452 - 1457 (2007/10/02)

The syntheses of N,N-dimethyl-6,7,8,9-tetrahydro-3H,10H-pyrrolocarbazol-7-amine (8), N,N-dimethyl-7,8,9,10-tetrahydro-11H-pyridocarbazol-8-amine (9a), and the N,N,11-trimethyl analogue (9b) are described.The in vitro inotropic activity of these compounds, as well as the known cardiotonics amrinone and 7-hydroxycyclindole (7), was investigated.Compound 8, a pyrrolo analogue of 7, was devoid of inotropic activity, while the pyrido analogues 9 were equiactive to 7 and amrinone.These results suggest that the hydroxyl group of 7 functions as an H-bondacceptor, rather than a donor, and that on interaction of 7, and the pyrido analogues 9, with a common receptor, an orbital occupied by one of the oxygen lone pair electrons of 7 must assume the same orientation as the orbital occupied by the pyridine nitrogen lone pair.

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