N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1439877-68-5
Molecular Formula:C₂₈H₂₃F₃N₄O₅
Molecular Weight:557.47
Hs Code.:

Synonyms:N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 11 articles about N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1516-08-1
ethanol-d6

: 1439876-69-3
N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

: 1439877-68-5
N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: ethanol-d6; With sodium hydride; In tetrahydrofuran; mineral oil;

N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; In tetrahydrofuran; mineral oil; at 15 - 25 ℃; for 1.5h;

Reference yield:

: 17368-12-6
2-chloropyridin-4-ol

: 1439877-68-5
N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 15 - 25 °C

1.2: 1.17 h

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / 1,4-dioxane / 4 h / 85 °C / Inert atmosphere

3.1: ammonium chloride; iron / water; ethanol / 1 h / 80 °C

4.1: pyridine / dichloromethane; thionyl chloride / 2.5 h / 0 - 25 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil

5.2: 1.5 h / 15 - 25 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; potassium carbonate; ammonium chloride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; thionyl chloride; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 35260-93-6,932750-29-3
ethyl 2-cyano-3-ethoxybut-2-enoate

: 1439877-68-5
N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-4-(ethoxy-d5)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2 h / 70 °C

2.1: acetic acid / Reflux

3.1: copper diacetate; pyridine / dichloromethane / 4 h / 15 - 25 °C

4.1: lithium hydroxide; water / ethanol / 16 h / 15 - 25 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / Reflux

6.1: pyridine / dichloromethane; thionyl chloride / 2.5 h / 0 - 25 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil

7.2: 1.5 h / 15 - 25 °C

With pyridine; thionyl chloride; water; copper diacetate; sodium hydride; acetic acid; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; thionyl chloride; ethanol; dichloromethane; toluene; mineral oil;