Technology Process of 4-ethoxy-1-(4-fluoro-phenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride
There total 7 articles about 4-ethoxy-1-(4-fluoro-phenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride;
for 1h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid / 120 - 130 °C
2.1: 2 h / 70 °C
3.1: acetic acid / Reflux
3.2: pH ~ 9 - 10
4.1: pyridine / copper diacetate / dichloromethane / 4 h / 25 °C
5.1: water; lithium hydroxide / ethanol / 16 h / 25 °C
5.2: pH < 2
6.1: thionyl chloride / 1 h / 60 °C
With
pyridine; thionyl chloride; water; acetic acid; lithium hydroxide;
copper diacetate;
In
ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine / copper diacetate / dichloromethane / 4 h / 25 °C
2.1: water; lithium hydroxide / ethanol / 16 h / 25 °C
2.2: pH < 2
3.1: thionyl chloride / 1 h / 60 °C
With
pyridine; thionyl chloride; water; lithium hydroxide;
copper diacetate;
In
ethanol; dichloromethane;