N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine

Base Information

• Chemical Name: N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine
• CAS No.: 169883-31-2
• Molecular Formula: C₁₇H₂₂BrN₃O
• Molecular Weight: 364.285

Synonyms:N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine

Chemical Property of N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine

Chemical Property:

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Technology Process of N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine

There total 6 articles about N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

1H-imidazole (288-32-4) + 2-(N-(2-bromo-4-isopropylphenyl)-N-ethyl)-6-methyl-4-(methanesulfonyloxy-methyl)pyrimidin-2-amine (169883-22-1) → N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine (169883-31-2) + N-{2-bromo-4-(1-methylethyl)phenyl}-N-ethyl-4-(imidazol-1-yl)methyl-6-methylpyrimidinamine

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 68h;

Reference yield:

methyl 2-((2-bromo-4-(1-methylethyl)-phenyl)-ethylamino)-6-methyl-4-pyrimidinaminecarboxylate → N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine (169883-31-2)

Guidance literature:

With lithium borohydride; In tetrahydrofuran;

Reference yield:

methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate (169880-48-2) → N-(2-Bromo-4-(1-Methylethyl)Phenyl)-N-Ethyl-4-Methyl-6-(Hydroxymethyl)-2-Pyrimidinamine (169883-31-2)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 19h;

DOI:10.1016/S0968-0896(99)00182-0

upstream raw materials:

methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

2-bromo-4-isopropylaniline

methyl 2-chloro-6-methylpyrimidine-4-carboxylate

2-(N-(2-bromo-4-(2-propyl)phenyl)amino)-4-carbomethoxy-6-methylpyrimidinamine

Downstream raw materials:

2-(N-(2-bromo-4-isopropylphenyl)-N-ethyl)-6-methyl-4-(methanesulfonyloxy-methyl)pyrimidin-2-amine

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