methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

Base Information

Chemical Name:methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate
CAS No.:169880-48-2
Molecular Formula:C₁₈H₂₂BrN₃O₂
Molecular Weight:392.296
Hs Code.:

Synonyms:methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

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Chemical Property of methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

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Technology Process of methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

There total 4 articles about methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 75-03-6
ethyl iodide

: 257615-17-1
2-(N-(2-bromo-4-(2-propyl)phenyl)amino)-4-carbomethoxy-6-methylpyrimidinamine

: 169880-48-2
methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 5h;
DOI:10.1016/S0968-0896(99)00182-0

Reference yield:

: 51605-97-1
2-bromo-4-isopropylaniline

: 169880-48-2
methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / dioxane / 24 h / Heating

2: 55 percent / NaH / dimethylformamide / 5 h

With sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation;
DOI:10.1016/S0968-0896(99)00182-0

Reference yield:

: 89793-11-3
methyl 2-chloro-6-methylpyrimidine-4-carboxylate

: 169880-48-2
methyl 2-((2-bromo-4-(1-methylethyl)phenyl)ethylamino)-6-methyl-4-pyrimidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / dioxane / 24 h / Heating

2: 55 percent / NaH / dimethylformamide / 5 h

With sodium hydride; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Alkylation / 2: Alkylation;
DOI:10.1016/S0968-0896(99)00182-0