1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester
• CAS No.: 1085839-59-3
• Molecular Formula: C₂₄H₂₂F₃N₃O₄
• Molecular Weight: 473.452
• Mol file: 1085839-59-3.mol

Synonyms:1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester

Chemical Property of 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester

There total 5 articles about 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-(4-aminophenyl)piperidine-4-carboxylate (471938-27-9) + 2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl chloride (845782-70-9) → 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester (1085839-59-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

isonipecotic acid methyl ester (2971-79-1) → 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester (1085839-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / 150 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 2585.81 Torr

3: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

4-Fluoronitrobenzene (350-46-9,178603-76-4) → 1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid methyl ester (1085839-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1.5 h / 150 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 2585.81 Torr

3: triethylamine / dichloromethane / 3 h / 20 °C

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

methyl 1-(4-aminophenyl)piperidine-4-carboxylate

2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl chloride

isonipecotic acid methyl ester

2-phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid

Downstream raw materials:

1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carboxylic acid

1-(1-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-piperidine-4-carbonyl)-piperidine-4-carboxylic acid ethyl ester