Welcome to LookChem.com Sign In|Join Free

CAS

  • or

2971-79-1

Post Buying Request

2971-79-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

2971-79-1 Usage

Chemical Properties

Colorless liquid

Uses

Different sources of media describe the Uses of 2971-79-1 differently. You can refer to the following data:
1. Methyl piperidine-4-carboxylate is a reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation. It is used as a reactant for synthesis of antitubercular agents, aminopyrazine inhibitors, orally available naphthyridine protein kinase D inhibitors and a scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide.
2. Methyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens.
3. 4-Piperidinecarboxylic acid methyl ester is a an ester derivative of 4-piperidinecarboxylic acid used as a reagent in the organic synthesis of neurochemicals, antibacterials and other biologically active compounds.

General Description

Methyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C.

Check Digit Verification of cas no

The CAS Registry Mumber 2971-79-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,7 and 1 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2971-79:
(6*2)+(5*9)+(4*7)+(3*1)+(2*7)+(1*9)=111
111 % 10 = 1
So 2971-79-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO2/c1-10-7(9)6-2-4-8-5-3-6/h6,8H,2-5H2,1H3

2971-79-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (M2075)  Methyl 4-Piperidinecarboxylate  >98.0%(T)

  • 2971-79-1

  • 5g

  • 350.00CNY

  • Detail
  • TCI America

  • (M2075)  Methyl 4-Piperidinecarboxylate  >98.0%(T)

  • 2971-79-1

  • 25g

  • 990.00CNY

  • Detail
  • Alfa Aesar

  • (H61754)  Methyl piperidine-4-carboxylate, 98%   

  • 2971-79-1

  • 25g

  • 297.0CNY

  • Detail
  • Alfa Aesar

  • (H61754)  Methyl piperidine-4-carboxylate, 98%   

  • 2971-79-1

  • 100g

  • 1066.0CNY

  • Detail
  • Aldrich

  • (463485)  Methylisonipecotate  technical grade

  • 2971-79-1

  • 463485-25ML

  • 456.30CNY

  • Detail
  • Aldrich

  • (463485)  Methylisonipecotate  technical grade

  • 2971-79-1

  • 463485-100ML

  • 1,320.93CNY

  • Detail

2971-79-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name METHYL 4-PIPERIDINECARBOXYLATE

1.2 Other means of identification

Product number -
Other names methyl isonipicotate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2971-79-1 SDS

2971-79-1Relevant articles and documents

A polymeric and fluorescent gel for combinatorial screening of catalysts [23]

Harris,Nation,Copeland,Miller

, p. 11270 - 11271 (2000)

-

Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture

Kühl, Nikos,Leuthold, Mila M.,Behnam, Mira A. M.,Klein, Christian D.

supporting information, p. 4567 - 4587 (2021/05/06)

The viral serine protease NS2B-NS3 is one of the promising targets for drug discovery against dengue virus and other flaviviruses. The molecular recognition preferences of the protease favor basic, positively charged moieties as substrates and inhibitors, which leads to pharmacokinetic liabilities and off-target interactions with host proteases such as thrombin. We here present the results of efforts that were aimed specifically at the discovery and development of noncharged, small-molecular inhibitors of the flaviviral proteases. A key factor in the discovery of these compounds was a cellular reporter gene assay for the dengue protease, the DENV2proHeLa system. Extensive structure-activity relationship explorations resulted in novel benzamide derivatives with submicromolar activities in viral replication assays (EC50 0.24 μM), selectivity against off-target proteases, and negligible cytotoxicity. This structural class has increased drug-likeness compared to most of the previously published active-site-directed flaviviral protease inhibitors and includes promising candidates for further preclinical development.

Design and Synthesis of 56 Shape-Diverse 3D Fragments

Atobe, Masakazu,Blakemore, David C.,Bond, Paul S.,Chan, Ngai S.,De Fusco, Claudia,Downes, Thomas D.,Firth, James D.,Hubbard, Roderick E.,Jones, S. Paul,Klein, Hanna F.,O'Brien, Peter,Roughley, Stephen D.,Vidler, Lewis R.,Waddelove, Laura,Whatton, Maria Ann,Wheldon, Mary C.,Woolford, Alison J.-A.,Wrigley, Gail L.

supporting information, (2020/07/13)

Fragment-based drug discovery is now widely adopted for lead generation in the pharmaceutical industry. However, fragment screening collections are often predominantly populated with flat, 2D molecules. Herein, we describe a workflow for the design and synthesis of 56 3D disubstituted pyrrolidine and piperidine fragments that occupy under-represented areas of fragment space (as demonstrated by a principal moments of inertia (PMI) analysis). A key, and unique, underpinning design feature of this fragment collection is that assessment of fragment shape and conformational diversity (by considering conformations up to 1.5 kcal mol?1 above the energy of the global minimum energy conformer) is carried out prior to synthesis and is also used to select targets for synthesis. The 3D fragments were designed to contain suitable synthetic handles for future fragment elaboration. Finally, by comparing our 3D fragments with six commercial libraries, it is clear that our collection has high three-dimensionality and shape diversity.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

-

Page/Page column 33, (2016/03/13)

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2971-79-1