Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate

Base Information

Chemical Name:Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate
CAS No.:157528-13-7
Molecular Formula:C₂₅H₂₇NO₅
Molecular Weight:421.493
Hs Code.:

Methyl 2-<N-(tert-butyloxycarbonyl)-N-methylamino>-4-(benzyloxy)-1-naphthalenecarboxylate

Synonyms:Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate

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Chemical Property of Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate

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Technology Process of Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate

There total 3 articles about Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 79-22-1
methyl chloroformate

: 157528-12-6
2--4-(benzyloxy)-1-bromonaphthalene

: 157528-13-7
Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; diethyl ether; 1.) -78 deg C, 15 min, 2.) -78 deg C, 30 min; -78 to 25 deg C, 2 h;
DOI:10.1021/jo00096a043

Reference yield:

: 122745-36-2
N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine

: 157528-13-7
Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / conc. H₂SO₄, NBS / tetrahydrofuran / 1.) -78 deg C, 5 min, 2.) -78 deg C, 5 h

2: 94 percent / NaH / dimethylformamide / 1.) 25 deg C, 30 min, 2.) 25 deg C, 2 h

3: 79 percent / n-BuLi / diethyl ether; tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) -78 deg C, 30 min; -78 to 25 deg C, 2 h

With N-Bromosuccinimide; n-butyllithium; sulfuric acid; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00096a043

Reference yield:

: 122745-37-3
2-((tert-Butyloxycarbonyl)amino)-4-(benzyloxy)-1-bromonaphthalene

: 157528-13-7
Methyl 2--4-(benzyloxy)-1-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NaH / dimethylformamide / 1.) 25 deg C, 30 min, 2.) 25 deg C, 2 h

2: 79 percent / n-BuLi / diethyl ether; tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) -78 deg C, 30 min; -78 to 25 deg C, 2 h

With n-butyllithium; sodium hydride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00096a043