122745-36-2

Basic information

• Product Name: Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester
• CAS NO: 122745-36-2
• Molecular Formula: C22H23NO3
• Molecular Weight: 349.43
• Mol File: 122745-36-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester(122745-36-2)
• EPA Substance Registry System: Carbamic acid, [4-(phenylmethoxy)-2-naphthalenyl]-, 1,1-dimethylethyl ester(122745-36-2)

Safety Data

• Hazardous Substances Data: 122745-36-2(Hazardous Substances Data)

Upstream product

• 34205-71-5 methyl 4-hydroxy-2-naphthalenecarboxylate 
• 132-86-5 1,3-dihydroxynaphthalene 
• 100-39-0 benzyl bromide 
• 606-37-1 2,4-dinitronaphthalene 
• 139975-98-7 tert-butyl-(4-hydroxynaphthalen-2-yl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 122745-35-1 3-Amino-1-(benzyloxy)naphthalene 
• 501440-80-8 3-(N-tert-butyloxycarbonyl)amino-1-O-(tertbutyloxycarbonyl)-1-naphthol 
• 2764-95-6 4-methoxy-2-naphthylamine 
• 13802-40-9 1-Methoxy-3-nitronaphthalene 
• 19256-80-5 3-Nitro-1-naphthol 

Downstream Products

• 1116653-76-9 (R)-tert-butyl (4-(benzyloxy)-1-iodonaphthalen-2-yl)(oxiran-2-ylmethyl)carbamate 
• 244154-66-3 tert-butyl (S)-1-(chloromethyl)-5-((4-methylpiperazine-1-carbonyl)oxy)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 129918-00-9 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-methyl-3H-benzindole 
• 128228-77-3 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole, (R)-(-)-O-acetyl mandelate ester 
• 128228-76-2 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole, (R)-(-)-O-acetylmandelate ester 
• 128300-12-9 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole 

Relevant articles and documents

CYTOTOXIC AGENTS

The present invention provides a compound of formula (I): (T-X4)p-B1-X3-A-X2-L-X1-AM or pharmaceutically acceptable salts, tautomers, stereoisomers or mixtures thereof; wherein AM is (AM1); (AM2); or (AM3); with the proviso that the compound of formula (I) contains at least one sigma hole group; and with the proviso that no more than one of A, B1 and T is a sigma hole group; and each sigma hole group is independently: (SH1); (SH2); (SH3); (SH4); (SH5); (SH6); (SH7); (SH8); (SH9); or (SH10).

ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS

Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.

CHEMICAL LINKERS AND CLEAVABLE SUBSTRATES AND CONJUGATES THEREOF

The present disclosure provides drug-ligand conjugates and drug-cleavable substrate conjugates that are potent cytotoxins. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.