(3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Base Information

Chemical Name:(3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide
CAS No.:1361330-10-0
Molecular Formula:C₂₈H₂₉F₂N₅O₅S
Molecular Weight:585.632
Hs Code.:

Synonyms:(3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

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Chemical Property of (3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

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Technology Process of (3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

There total 14 articles about (3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₆F₂N₄O₈S

: 1361330-10-0
(3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-4-3-morpholinecarboxamide

: 1361330-10-0
(3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

: 1361330-09-7
(3R)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Guidance literature:: With Chiralpak IA column; In ethanol; n-heptane; Resolution of racemate;

Reference yield:

: 608515-57-7
2,4-difluoro-6-methoxybenzaldehyde

: 1361330-10-0
(3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / 3 h / 110 °C

2.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: pyridine / 18 h / 21 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

6.1: HATU / N,N-dimethyl-formamide / 0.05 h / Inert atmosphere

6.2: 0.05 h

6.3: 3 h

7.1: trifluoroacetic acid / dichloromethane / 1 h

With pyridine; lithium aluminium tetrahydride; hydrazine hydrate; HATU; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;