608515-57-7

Basic information

• Product Name: 2,4-Difluoro-6-methoxybenzaldehyde
• Synonyms: 2,4-Difluoro-6-methoxybenzaldehyde;2-Formyl-3,5-difluoroanisole
• CAS NO: 608515-57-7
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.1288464
• Mol File: 608515-57-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,4-Difluoro-6-methoxybenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluoro-6-methoxybenzaldehyde(608515-57-7)
• EPA Substance Registry System: 2,4-Difluoro-6-methoxybenzaldehyde(608515-57-7)

Safety Data

• Hazardous Substances Data: 608515-57-7(Hazardous Substances Data)

Usage

General Description

2,4-Difluoro-6-methoxybenzaldehyde is a chemical compound with the molecular formula C9H7F2O2. It is a benzaldehyde derivative with two fluorine atoms and a methoxy group attached to the benzene ring. 2,4-Difluoro-6-methoxybenzaldehyde is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and agrochemicals. It has also been studied for its potential applications in material science and chemical research. 2,4-Difluoro-6-methoxybenzaldehyde is known for its strong aromatic scent and is handled with caution due to its potential irritant and toxic properties.

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 93343-10-3 3,5-difluoroanisol 
• 65611-08-7 dichloromethyl propyl ether 
• 5312-73-2 dichloromethyl n-butyl ether 
• 352-32-9 p-fluorotoluene 
• 5374-05-0 (dichloromethoxy)ethane 
• 2713-34-0 3,5-difluorophenol 

Downstream Products

• 1240518-41-5 2,4-difluoro-6-methoxybenzonitrile 
• 1240518-47-1 N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide formate 
• 1240517-58-1 N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]acetamide 
• 1240517-61-6 N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide 
• 1240518-44-8 5-chloro-N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide 
• 1240518-46-0 N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-5-chloro-2-thiophenesulfonamide 
• 1361330-11-1 N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide 
• 1361330-10-0 (3S)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide 
• 1361330-09-7 (3R)-N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-3-morpholinecarboxamide 
• 1361330-37-1 N-[1-{[3-(aminomethyl)phenyl]methyl}-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide 
• 1361330-36-0 N-[1-[(3-cyanophenyl)methyl]-6-fluoro-4-(methyloxy)-1H-indazol-3-yl]-3-fluoro-4-methylbenzenesulfonamide 
• 1240518-43-7 3-{[3-amino-6-fluoro-4-(methyloxy)-1H-indazol-1-yl]methyl}benzonitrile 
• 1240518-42-6 6-fluoro-4-methoxy-1H-indazol-3-amine 
• 136516-64-8 2,4-difluoro-6-hydroxy-benzaldehyde 

Relevant articles and documents

Direct formylation of fluorine-containing aromatics with dichloromethyl alkyl ethers

Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.

IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER

A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R3, R4, R6, and R7 are as defined herein.

NOVEL COMPOUNDS

Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.