(1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol

Base Information

Chemical Name:(1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol
CAS No.:438497-41-7
Molecular Formula:C₁₉H₂₄O₂SSe
Molecular Weight:395.424
Hs Code.:

Synonyms:(1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol

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Chemical Property of (1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol

Chemical Property:

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Technology Process of (1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol

There total 6 articles about (1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 637-50-3
1-phenylpropene

: 438497-45-1
C₁₀H₁₄O₅S₂Se

: 438497-41-7
(1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol

Guidance literature:: With water; In acetonitrile; at -30 ℃; for 24h;
DOI:10.1002/1521-3765(20020301)8:5<1118::AID-CHEM1118>3.0.CO;2-2

Reference yield:

: 23308-82-9,89691-63-4,120523-12-8,129940-69-8
(R)-(+)-1-(3-methoxyphenyl)-1-ethanol

: 438497-41-7
(1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: KOH / diethyl ether / 24 h / -20 °C

2.1: diethyl ether / 12 h / 20 °C

3.1: t-BuLi / pentane / 0.75 h / -78 - 25 °C

3.2: 70 percent / Se / pentane; tetrahydrofuran / 12 h / 20 °C

4.1: (NH₄)2S₂O₈; CF₃SO₃H / CH₂Cl₂ / 0.25 h / 20 °C

5.1: H₂O / acetonitrile / 24 h / -30 °C

With potassium hydroxide; ammonium peroxydisulfate; trifluorormethanesulfonic acid; water; tert.-butyl lithium; In diethyl ether; dichloromethane; acetonitrile; pentane;
DOI:10.1002/1521-3765(20020301)8:5<1118::AID-CHEM1118>3.0.CO;2-2

Reference yield:

: 586-37-8
1-(3-Methoxyphenyl)ethanone

: 438497-41-7
(1R,2S)-2-({2-methoxy-6-[(1S)-1-(methylthio)ethyl]phenyl}seleno)-1-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: (+)-β-chlorodiisopinocampheylborane / tetrahydrofuran / -20 °C

2.1: KOH / diethyl ether / 24 h / -20 °C

3.1: diethyl ether / 12 h / 20 °C

4.1: t-BuLi / pentane / 0.75 h / -78 - 25 °C

4.2: 70 percent / Se / pentane; tetrahydrofuran / 12 h / 20 °C

5.1: (NH₄)2S₂O₈; CF₃SO₃H / CH₂Cl₂ / 0.25 h / 20 °C

6.1: H₂O / acetonitrile / 24 h / -30 °C

With potassium hydroxide; ammonium peroxydisulfate; trifluorormethanesulfonic acid; water; tert.-butyl lithium; B-chlorodiisopinocampheylborane; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile; pentane;
DOI:10.1002/1521-3765(20020301)8:5<1118::AID-CHEM1118>3.0.CO;2-2