toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester

Base Information

Chemical Name:toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester
CAS No.:384344-34-7
Molecular Formula:C₆₆H₅₇N₃O₅S₇
Molecular Weight:1196.66
Hs Code.:

Synonyms:toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester

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Chemical Property of toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester

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Technology Process of toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester

There total 7 articles about toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 384344-18-7
2,6-bis(phenylthiomethyl)-3-hydroxypyridine

: 384344-24-5
2,6-bis[((3-hydroxymethylphenyl)thio)methyl]-3-hydroxypyridine p-toluenesulfonate

: 384344-34-7
toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 24h;
DOI:10.1016/S0040-4020(01)00871-7

Reference yield:

: 14187-25-8
3-hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride

: 384344-34-7
toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: conc. HBr / 6 h / Heating

2: 83 percent / KOH / dimethylsulfoxide / 1 h / 25 °C

3: 66 percent / PPh₃; DEAD / tetrahydrofuran / 24 h / 25 °C

With potassium hydroxide; hydrogen bromide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dimethyl sulfoxide; 3: Mitsunobu reaction;
DOI:10.1016/S0040-4020(01)00871-7

Reference yield:

: 83794-86-9
3-mercaptobenzyl alcohol

: 384344-34-7
toluene-4-sulfonic acid 2,6-bis-[3-(2,6-bis-phenylsulfanylmethyl-pyridin-3-yloxymethyl)-phenylsulfanylmethyl]-pyridin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

1.2: 79 percent / 18-crown-6 / dimethylformamide / 24 h / 45 °C

2.1: 66 percent / PPh₃; DEAD / tetrahydrofuran / 24 h / 25 °C

With potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: Mitsunobu reaction;
DOI:10.1016/S0040-4020(01)00871-7