3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride

Base Information

• Chemical Name: 3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride
• CAS No.: 14187-25-8
• Molecular Formula: C7H9 N O3 . Cl H
• Molecular Weight: 191.614
• Hs Code.: 2933399090
• European Community (EC) Number: 624-515-0
• DSSTox Substance ID: DTXSID90497162
• NSC Number: 89708
• Mol file: 14187-25-8.mol

Synonyms:14187-25-8;3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride;2,6-bis(hydroxymethyl)pyridin-3-ol hydrochloride;3-Hydroxy-2,6-di(hydroxymethyl)pyrridine hydrochloride;2,6-bis(hydroxymethyl)pyridin-3-ol;hydrochloride;2,6-Bis(hydroxymethyl)-3-hydroxypyridine hydrochloride;DTXSID90497162;NSC89708;MFCD00035338;NSC-89708;AKOS024323257;J-007563;2,6-Bis(hydroxymethyl)pyridin-3-ol--hydrogen chloride (1/1);3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride, 97%

Chemical Property of 3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride

Chemical Property:

• Vapor Pressure: 6.31E-10mmHg at 25°C
• Melting Point: 142-147 °C
• Boiling Point: 477.5oC at 760 mmHg
• Flash Point: 242.6oC
• PSA: 73.58000
• LogP: 0.57380
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 191.0349209
• Heavy Atom Count: 12
• Complexity: 120

Purity/Quality:

98%min ^*data from raw suppliers

3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(N=C1CO)CO)O.Cl

Technology Process of 3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride

There total 2 articles about 3-Hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-HYDROXYPYRIDINE (109-00-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 3-hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride (14187-25-8)

Guidance literature:

3-HYDROXYPYRIDINE; formaldehyd; With sodium hydroxide;

With hydrogenchloride; Further stages.;

DOI:10.1016/j.tetlet.2007.03.024

Reference yield:

2,6-bis-(hydroxymethyl)-3-hydroxypyridine (38029-16-2) → 3-hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride (14187-25-8)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide; Yield given;

DOI:10.1055/s-1987-28060

Reference yield: 85.0%

3-hydroxy-2,6-bis(hydroxymethyl)pyridine hydrochloride (14187-25-8) + p-toluenesulfonyl chloride (98-59-9) → 2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate (384344-20-1)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 24h;

DOI:10.1016/S0040-4020(01)00871-7

upstream raw materials:

2,6-bis-(hydroxymethyl)-3-hydroxypyridine

3-HYDROXYPYRIDINE

formaldehyd

Downstream raw materials:

2,6-bis-(hydroxymethyl)-3-hydroxypyridine

2,6-bis(hydroxymethyl)-3-hydroxypyridine p-toluenesulfonate

C₂₉H₂₉NO₃S

C₃₀H₃₆N₆O₁₁S₂