(+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid

Base Information

• Chemical Name: (+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid
• CAS No.: 177587-71-2
• Molecular Formula: C₂₃H₃₀O₄
• Molecular Weight: 370.489
• Mol file: 177587-71-2.mol

Synonyms:(+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid

Chemical Property of (+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid

There total 3 articles about (+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionate (177587-70-1) → (+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid (177587-71-2)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1021/jm990135j

Reference yield:

ethyl 3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylacrylate → (+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid (177587-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5 percent Pd/C / ethanol

2: 99 percent / aq. KOH / ethanol

With potassium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; 1: Hydrogenation / 2: Hydrolysis;

DOI:10.1021/jm990135j

Reference yield:

→ (+/-)-3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionic acid (177587-71-2)

Guidance literature:

upstream raw materials:

ethyl 3-[4-methoxy-3-(2-phenylethoxy)phenyl]-2-pentylpropionate

Downstream raw materials:

(+/-)-N-tert-butoxycarbonyl-1-pentyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine